Biohacking Stack Synergy Calculator

Calculate synergy scores for nootropic and supplement stacks. Find science-backed combinations that enhance cognitive performance, recovery, and well-being.

Select a pre-built biohacking stack or choose custom

Only used if Custom selected above (max 5 ingredients)

Used to calculate appropriate dosages

Synergy Score = Base Stack Synergy + Goal Alignment Bonus. Dose = Base Dose × Experience Multiplier × Sensitivity Adjustment × (Body Weight / 70kg). Effectiveness = 60 + (Synergy × 0.3) + Experience Bonus.
Focus Stack (Caffeine 200mg + L-Theanine 400mg + Alpha-GPC 300mg) for 70kg intermediate user: Synergy Score 85/100, Effectiveness ~86%, optimal timing: morning empty stomach.

What is supplement synergy in biohacking?

Supplement synergy occurs when two or more compounds work together to produce effects greater than the sum of their individual effects. For example, caffeine (stimulant) + L-Theanine (relaxant) creates alert calmness without jitters. Magnesium enhances sleep when paired with Glycine. Synergy is calculated based on pharmacokinetic and pharmacodynamic interactions.

How is synergy score calculated?

Synergy score (0-100) is calculated by analyzing: 1) Mechanism overlap (same pathway = higher synergy), 2) Pharmacokinetic compatibility (absorption/timing), 3) Dose-response linearity, 4) Bioavailability enhancement. High-synergy combinations can increase effectiveness by 40-80% compared to individual ingredients.

What are the best nootropic synergies?

Top synergies include: Caffeine + L-Theanine (reduces jitters, extends focus), Bacopa + Lion's Mane (neurogenesis + memory consolidation), Alpha-GPC + Caffeine (enhanced acetylcholine + alertness), Omega-3 + Vitamin D3 (brain health synergy), Magnesium + Glycine (deep sleep enhancement).

Are there negative interactions to avoid?

Yes, avoid: Stimulants late in day (caffeine after 2pm), 5-HTP + SAMe (serotonin syndrome risk), high-dose iron with zinc/magnesium (compete for absorption), blood thinners with high-dose fish oil, adaptogens during acute infection. Always start with low doses and monitor effects.