NAD+ Dosage Calculator
Find your optimal NAD+ precursor supplement dosage. Enter your age, weight, and goals to get personalized NMN, NR, and other NAD+ booster recommendations.
Your current age
Your body weight in pounds
Type of NAD+ precursor supplement
Your intended use for NAD+ supplementation
How often you plan to supplement
What is NAD+ and why does it decline with age?
NAD+ (Nicotinamide Adenine Dinucleotide) is a crucial coenzyme found in every cell of your body. It plays essential roles in energy production, DNA repair, cellular signaling, and sirtuin activation. NAD+ levels decline by approximately 50% from age 20 to 60 due to increased consumption for DNA repair, inflammation, and metabolic processes. This decline is linked to accelerated aging, reduced energy, cognitive decline, and metabolic dysfunction.
What is the difference between NMN, NR, and other NAD+ precursors?
NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are the most researched NAD+ precursors. NMN is one step closer to NAD+ in the biosynthesis pathway and may be more efficient. NR was the first NAD+ precursor supplement to be widely studied and has strong human trial data. Both convert to NAD+ in the body. Nicotinamide (NAM) is another precursor but at high doses may inhibit sirtuins. Niagen is a patented form of NR from ChromaDex.
How much NAD+ precursor should I take?
Clinical studies typically use 250-500mg of NMN or NR daily. This calculator adjusts based on your weight, age, and goals. Older individuals and those seeking therapeutic benefits may benefit from higher doses. Start with a lower dose and gradually increase to assess tolerance. Consult a healthcare provider before starting high-dose supplementation, especially if you have medical conditions or take medications.
When is the best time to take NAD+ precursors?
Most research suggests taking NAD+ precursors in the morning or early afternoon, as NAD+ levels naturally peak during the day and decline at night. Taking them too close to bedtime may interfere with sleep in some sensitive individuals. Consistency is more important than timing—choose a time you can take daily. Some protocols recommend cycling NAD+ precursors (e.g., 4 weeks on, 1 week off) to prevent receptor downregulation.
What side effects should I watch for with NAD+ supplementation?
NAD+ precursors are generally well-tolerated. Minor side effects may include nausea, flushing, headache, or fatigue during the first week as NAD+ levels rise. High doses of nicotinamide (NAM) may cause liver toxicity if taken long-term. If you experience persistent discomfort, reduce the dose. People with cancer, pregnancy, or breastfeeding should consult a doctor before using NAD+ boosters.