Rapamycin Longevity Dose Calculator
Get personalized Rapamycin dosing recommendations for longevity protocols. Calculate your optimal dose based on weight and goals.
Your body weight in pounds
Your current age (Rapamycin typically used 40+)
Your intended use of Rapamycin
How often you plan to take Rapamycin
How long you plan to use Rapamycin
What is Rapamycin and how does it work for longevity?
Rapamycin (sirolimus) is an FDA-approved immunosuppressant drug originally used to prevent organ transplant rejection. It inhibits mTOR (mechanistic target of rapamycin), a key protein pathway that regulates cell growth, metabolism, and aging. When mTOR is inhibited, cells enter a protective state called autophagy (cellular cleanup) and metabolic processes shift toward maintenance and repair rather than growth. Animal studies show Rapamycin can extend lifespan by 25-50% in mice, making it one of the most promising longevity interventions.
What is the typical Rapamycin dosage for longevity?
Clinical protocols for longevity typically use 5-15mg taken once per week. The Peter Attia protocol commonly uses 5-10mg weekly. Dr. Brad Stanfield's protocol suggests 5mg weekly for healthspan benefits. Some protocols use 10mg every 2 weeks or 5mg for 5 consecutive days every 2 weeks. Doses above 15mg weekly are associated with more pronounced side effects and typically reserved for therapeutic applications under medical supervision.
What are the side effects and risks of Rapamycin?
Common side effects include mouth sores (mucositis), increased cholesterol, decreased white blood cells, and immunosuppression. Long-term risks include impaired wound healing, proteinuria, and metabolic effects. Some users report fatigue, headache, or GI issues. Because Rapamycin suppresses immune function, you should avoid live vaccines and be cautious during illness. NEVER take Rapamycin without medical supervision from a doctor familiar with this protocol.
Can I take Rapamycin with other supplements like NMN or metformin?
Combining Rapamycin with other longevity compounds is common but should be medically supervised. NMN and Rapamycin both target aging pathways but work differently—NMN boosts NAD+ while Rapamycin inhibits mTOR. Some protocols pair them with metformin (another longevity drug), aspirin, and various supplements. However, drug interactions are possible. Do not combine treatments without consulting a healthcare provider familiar with longevity medicine.
How often should I monitor health markers while on Rapamycin?
Before starting: Get baseline blood work including CBC, CMP, lipid panel, fasting glucose, HbA1c, and inflammatory markers (hs-CRP). During treatment: Monitor monthly for the first 3 months, then every 3-6 months. Key markers to track include cholesterol panel, blood glucose, liver function, kidney function, and inflammatory markers. Report any unusual infections, mouth sores, or fatigue to your doctor immediately.